Tracing the Fate of Chromium Nutritional Supplements in the Body
نویسندگان
چکیده
Chromium has been proposed to be an essential trace element useful in the treatment of diabetes, and several chromium(III) compounds have been used as nutritional supplements. However, the fate of the chromium from nutritional supplements has been investigated solely by techniques, such as radio-labeling, which allow only the chromium atom to be traced, not its chemical form. This investigation examined the ability of liquid chromatography-mass spectrometry (LCMS) to follow these supplements and to elucidate the chemical composition of their degradation products in the body. Rats were utilized to examine chemical composition of a chromium supplement provided to the rats by gavage administration. Results indicate that LCMS is not a viable analytical technique for elucidating the speciation and quantification of chromium nutritional supplements at even pharmacological doses.
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